CLDN4 and colitis: The expression levels of these TJs in pretreated-Bifico-colitis and pretreated + treated-Bifico-colitis groups were extensively increased compared with the colitis group (P1 < 0.05 and P2 < 0.05 for JAM-1, P1 = 0.073 and P2 < 0.01 for occludin, and P1 = 0.598 and P2 < 0.05 for claudin-4).