The proportion of total CD4+ T cells in the peripheral blood in the colitis group was increased (colitis versus normal group: 55.10 ± 4.73 versus 34.19 ± 1.49, P < 0.01); however, compared with the colitis group, the increased proportion of total CD4+ T cells was partially reversed both in pretreated-Bifico-colitis (36.04 ± 3.99 versus 55.10 ± 4.73, P < 0.01) and pretreated + treated-Bifico-colitis groups (47.90 ± 3.66 versus 55.10 ± 4.73, P = 0.556) (Figure 5(a)). This evidence concerns the gene CD4 and colitis.