Compared with IL10−/− mice, DKO mice exhibited more severe colitis by histology (Figures 1(c) and 1(e)), greater colitis scores (colitis scores = 8.0 ± 0.6 versus 12.1 ± 0.7 in IL10−/− and DKO mice, respectively; p < 0.001, Figure 1(e)), and mucosal hypertrophy (Figure 1(f)). The gene discussed is IL10; the disease is colitis.