IL-1β-511CT and -511TT genotypes among alcohol users increased the risk of severe hepatotoxicity (42.9% versus 40.7%, OR = 1.64, 95% CI: 0.10–51.13, P = 0.84 and 42.9% versus 37.0%, OR = 1.80, 95% CI: 0.11–56.75, P = 0.90, resp). This evidence concerns the gene IL1B and hepatotoxicity.