IL1RN and hepatotoxicity: However, IL-1RN 1/3 genotype and allele 3 were overrepresented in HIV-infected individuals with hepatotoxicity compared with healthy controls (5.9% versus 2.0%, OR = 2.39, 95% CI: 0.37–15.33, P = 0.69 and 2.94% versus 1.64%, OR = 1.62, 95% CI: 0.20–8.57, P = 0.93, resp).