CASP1 and Parkinson disease: Specifically, caspase-1 inhibitors did not improve the survival of grafted dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- (MPTP-) induced PD models [120], and caspase-1 inhibitors could not prevent dopaminergic neuronal death in MPTP parkinsonian mice [121].