FRα is significantly up-regulated in a variety of epithelial cancers such as serous and endometrioid epithelial ovarian cancer (OC), endometrial adenocarcinoma, non-small cell lung cancer (NSCLC) of the adenocarcinoma subtype, and to a less extent in clear cell renal, colorectal and breast cancers to meet the folate demand of rapidly dividing cells under low folate conditions3–5. The gene discussed is FOLR1; the disease is non-small cell lung carcinoma.