This conclusion is based on following evidence: (1) Fungi infection can induce activation and degranulation of MCs in the limbus; (2) cromolyn, the MC stabilizer for degranulation, can significantly prolong the course of disease, increase pathological damage, and increase the perforation rate of fungal keratitis; (3) cromolyn reduces neutrophil infiltration to the site of the fungal infection in the central cornea; (4) MC activation can increase ICAM-1 expression. Here, ICAM1 is linked to fungal infectious disease.