Eight of the osteoporosis-related mRNAs were targets of both hsa-miR-122-5p and hsa-miR-4516, namely, BMP2 inducible kinase (BMP2K), follicle stimulating hormone beta subunit (FSHB), insulin-like growth factor 1 receptor (IGF1R), parathyroid hormone-like hormone (PTHLH), runt-related transcription factor 2 (RUNX2), Secreted protein acidic and cysteine rich (SPARC), TSC22 domain family member 3 (TSC22D3) and vitamin D (1,25-dihydroxy vitamin D3) receptor (VDR). Here, SPARC is linked to osteoporosis.