Besides this, we also found that some of the hub nodes in the network are not included in the AD-related gene dataset, such as the differentially expressed genes RXRA, STAT3, STAT1, PSMD14, and so forth, and the non-differentially expressed HNF4A, PGR, ESRRA, THRB, and so forth, which are worth paying more attention to in further study. Here, ESRRA is linked to Alzheimer disease.