On the other hand, we also found that some of the hub nodes in the network are not included in the RA-related gene dataset, such as differentially expressed genes GSK3B, SMARCA4, PSMD7, TGFBR1, and so forth, and non-differentially expressed genes HNF4A, PGR, RXRA, ESRRA, and so forth. Here, ESRRA is linked to rheumatoid arthritis.