PML and neoplasm: Thus, we recently demonstrated, after in vivo transplantation of L428 cells at different stages of antigen acquisition, that the pattern of TMMs evolves, with high telomerase expression in the small CD30−/CD15− cells, and progressive expression of an ALT profile until acquisition of the HRS cell phenotype, with predominant PML bodies, low telomerase expression [56], and the presence of tumor cells without TMM staining.