SNCA and Parkinson disease: Interestingly, the distribution of DAT staining appeared to retrace that observed for α-synuclein in PD patients and control subjects [27] where α-synuclein showed a sparse distribution in the caudate putamen of the controls (Figure 1C,F) and a widespread reduction with the presence of α-synuclein-positive LB (Figure 1L, arrow) and neuropil-like dots (Figure 1I,I1,L, arrowheads) in the PD subjects.