GNB3 and hypertensive disorder: Figure 1 demonstrated additive interactions between GNB3 gene polymorphisms and sodium intake in terms of synergism effects marked by red bar. We further focused on nonsmoking and nondrinking participants in the Supplement Table S2. It showed stronger synergistic effects of GNB3 C825T and dietary sodium intake on the development of hypertension (s = 5.22) (Supplement Figure S1).