In clear cell renal cell carcinoma, SF3B3 overexpression was found to increase the expression of the pro-proliferative full-length isoform of EZH2 and not the commonly expressed EZH2∆14 that is found in normal tissue (Chen et al. 2017), thus promoting tumourigenicity in vivo. Here, SF3B3 is linked to clear cell renal carcinoma.