Studies have shown that downregulation of the full-length nuclear BRCA1 isoform and overexpression of the cytoplasmic ∆11q isoform is evident in subsets of breast cancer and is potentially mediated through the presence of a non-functional TRA2β splicing factor (Raponi et al. 2014, Wiener et al. 2015). Here, BRCA1 is linked to breast carcinoma.