SF3B1 and breast cancer: For instance, MYC addicted TNBCs cells have been shown to impart a specific dependency on the spliceosome via BUD31 and SF3B1 (Hsu et al. 2015) and impaired tumourigenesis was observed when SF3B1 was knocked down or pharmacologically inhibited in breast cancer cells MYC hyperactivation (Hsu et al. 2015).