FGFR1 and breast cancer: Alternatively spliced isoforms of genes known to be transcriptionally regulated by the oestrogen receptor such as Cyclin D1 (cyclin D1b) and FGFR1 (FGFR1-beta) are also associated with poor prognosis in ER+ breast cancer (Wei et al. 2011, Wendt et al. 2014).