Interestingly, additional spliceosomal component genes are also recurrently mutated at high frequencies particularly in MDS, including U2AF1, which has a distinct S34F/Y hotspot mutation and mutations in SRSF2 that are associated with a poor outcome in MDS (Thol et al. 2012) and ZRSR2. Here, ZRSR2 is linked to myelodysplastic syndrome.