Despite its glycemic benefits, GIP was dismissed as a potential anti-obesity target due to some reports testifying GIP is obesogenic in nature in mice and certain cell lines (Eckel et al. 1979, Oben et al. 1991, Miyawaki et al. 2002, McClean et al. 2007, Althage et al. 2008, Gogebakan et al. 2012, Finan et al. 2016). Here, GIP is linked to obesity due to melanocortin 4 receptor deficiency.