Plasmodium falciparum reticulocyte–binding homologue-5 is a conserved malaria vaccine candidate that induces antibodies that are protective in in vitro assays,32 non-human primate studies7 and field studies.16,33Plasmodium falciparum reticulocyte–binding homologue-5 interacts with basigin (CD147), an erythrocyte surface protein, to allow the invasion of the malaria parasite into the erythrocyte. This evidence concerns the gene BSG and malaria.