BRAF and melanoma: Furthermore, the consensus panel noted that the combination of the BRAF and MEK inhibitors, dabrafenib and trametinib, respectively, was recently shown to be superior to placebo in patients with stage III melanoma with BRAF V600E/K mutations; these data provide the first evidence for significant RFS and OS benefit of a targeted antitumor therapy that does not fit the putative immunotherapy approach and can be considered for patients with tumors harboring BRAF mutations [32].