The panel recognizes several systemic treatment options for patients with unresectable stage IV melanoma, including immunotherapy with high-dose IL-2 (where available), ipilimumab, nivolumab, pembrolizumab, T-VEC (if accessible lesions are present), combination ipilimumab and nivolumab, clinical trial participation, and cytotoxic chemotherapy [7–12]. Here, IL2 is linked to melanoma.