By using this longitudinal analysis, our study identifies novel pathways (STAT4 and BCL6) that might be of relevance in sJIA and indicates strong upregulation of HLA-DRB1 in cooperation with CD74 in patients with sJIA in inactive disease upon treatment with IL-1 antagonists. The gene discussed is HLA-DRB1; the disease is systemic-onset juvenile idiopathic arthritis.