Certain genotypes of HLA-DRB1, most notably HLA-DRB1*11, have been found to be strongly associated with sJIA in a large recent study of 982 patients across nine different populations, and also in a fine-mapping study of the HLA locus comparing it to other forms of JIA [11, 15, 26]. Here, HLA-DRB1 is linked to systemic-onset juvenile idiopathic arthritis.