Statistically significant differences across the three PDQ classification groups were observed for tender joint count (TJC), tender point (TP) count, DAS28-CRP, physical function (HAQ-DI), VAS-fatigue, VAS-pain, VAS-GH, anxiety (GAD-10), depression (MDI), SF-36 PCS, and SF-36 MCS. Here, CRP is linked to depressive disorder.