In contrast to our hypothesis, a high PDQ score had no prognostic value in relation to treatment outcome specified as change in DAS28-CRP, RAMRIS score, DCE-MRI, or VAS pain 4 months after initiation or escalation of medical therapy, however, it was found that the RAMRIS synovitis score may have prognostic value in relation to DAS28-CRP response. This evidence concerns the gene CRP and synovitis.