By identifying LATS1/2 and Rho-GTPase as two synergistic instruments of STARD13-correlated ceRNA network in regulating breast CSC traits, our findings forge a novel and unanticipated collaboration between oncogenic Rho-GTPase/F-actin function and the tumor-suppressive Hippo pathway in breast cancer via ceRNA crosstalking. This evidence concerns the gene LATS1 and breast carcinoma.