These results suggest that resistin and visfatin, both as the proinflammatory factors, may exert a synergetic effect during the pathogenesis of atherosclerosis in these patients, and the circulating levels of resistin, vaspin, and visfatin may parallel the severity of systemic atherosclerosis, despite their roles as indicators of the extent of insulin resistance. The gene discussed is NAMPT; the disease is atherosclerosis.