However, increased IFNγ ELIspot T cell responses against H.influenzae showed significant positive association, albeit weak, with lung function (FEV1%) and negative association with BSI, which may suggest that T cells are protective against disease, in contrast to antibody responses which showed a negative correlation with FEV1%, and may simply be associated with more infection. This evidence concerns the gene IFNG and bathing suit ichthyosis.