Although a number of mutations of FGFR2 have been well characterized to date and a few mutations are identified affecting cell proliferation such as osteoblasts and chondrocytes in vitro, [9–11] however, to our knowledge, there is no literature reported the expression of osteoblasts and chondrocytes in vivo, especially in orbital bone from Crouzon syndrome patient. This evidence concerns the gene FGFR2 and Crouzon disease.