Although a number of mutations of FGFR2 have been well characterized to date and a few mutations are identified affecting cell proliferation such as osteoblasts and chondrocytes in vitro, [9–11] however, to our knowledge, there is no literature reported the expression of osteoblasts and chondrocytes in vivo, especially in orbital bone from Crouzon syndrome patient. Here, FGFR2 is linked to Crouzon syndrome.