These authors additionally found a strong association between vessel calcification volume in the aortic arch and carotid arteries and plasma vWF levels at the time of ischaemic event in 925 patients.87Longitudinal assessments further confirmed these associations between vWF and the development of atherosclerotic-driven stroke, suggesting a causative role of vWF in specific stroke sub-types.88 This evidence concerns the gene VWF and stroke disorder.