Several proteins have excellent biomarker potential to separate controls and glaucoma patients, including NPC2 (AUC = 0.793), COL18A1 (AUC = 0.790), NWD1 (AUC = 0.779), SERPINF2 (AUC = 0.771), TSPAN14 (AUC = 0.768), IGKC (AUC = 0.769), SUCGL2 (AUC = 0.761), ITIH4 (AUC = 0.758), and IDH3A (AUC = 0.751). The gene discussed is IDH3A; the disease is glaucoma.