PAN2 and retinal degeneration: One of the pathways that we focused on was inflammatory response; previous studies have evidenced that sustained chronic inflammatory process may contribute to the etiology of RP in rd10 mice and in other animal models of retinal degeneration.43, , –46 Furthermore, these studies support the notion that miRNAs are rapidly upregulated in response to inflammatory signals and may either stimulate the magnitude and duration of inflammation or silence it.47 Example of some of the genes related with inflammatory or immune response included Sema7a, Pan2, Pla2r1, Thbs1, or Trim36.