TLR2 and infection: Human conjunctival transcriptome studies in both active and scarring trachoma have shown prominent innate immune responses.11,12 Animal studies have shown neutrophil infiltration of the genital tract tissue following C. trachomatis inoculation and that the intensity of the infiltrate was related to subsequent fibrotic sequelae.31,32 Toll-like receptor-2 knockout mice were able to clear infection but had markedly reduced late oviduct pathology.33 A guinea pig model of trachoma looking at neutrophil depletion showed less inflammation clinically and fewer mucosal erosions histologically.34