An outstanding example of abnormal sialylation in disease is the near-universal overexpression of sialic acids in cancer [13–15], which drives multiple aspects of oncogenesis including disabling immunesurveillance by tempering immunity via the sialic acid binding immunoglobulin like lectin (SIGLEC) immunomodulatory signaling pathway [16–18]; facilitating metastasis [14,19,20]; and potentiating oncogenic surface receptors such as EGFR [21–23]. The gene discussed is EGFR; the disease is cancer.