To identify additional gene(s) that might have been knocked down by the Ildr2 shRNA, and thus have contributed to development of steatosis in ADKD mice, we performed RNA sequencing analysis on liver samples from ADKD and AD-lacZ mice (from our previously published ADKD study [4]) and Ildr2Adv KO mice (Fig 3). Here, ILDR2 is linked to Alzheimer disease.