We screened for candidate genes that were: 1) significantly decreased in ADKD vs. AD-lacZ; 2) significantly decreased in ADKD vs. Ildr2Adv KO; and, 3) not significantly changed between AD-lacZ and Ildr2Adv KO livers, indicating a specific effect of the KD Ildr2 shRNA shRNA (Fig 5D). The gene discussed is ILDR2; the disease is Alzheimer disease.