After induction of CAR expression with 10 or 1000 ng/ml DOX the low affinity CAR T cells displayed substantial CAR-mediated lysis against primary MM cells in the BM-MNC, but, as expected, there was little or no lysis of CD38+ non-MM cells even after using 1000 ng/ml of DOX (Fig 5 and S5 Fig). The gene discussed is CD38; the disease is Miyoshi myopathy.