However, gemcabene 100 and 300 mg/kg and telmisartan-treated groups down-regulated ADH-4 mRNA expression levels compared to the vehicle-treated NASH group (0.6 ± 0.1, 0.5 ± 0.1 and 0.6 ± 0.2, respectively, compared to 0.9 ± 0.3). Here, ADH4 is linked to metabolic dysfunction-associated steatohepatitis.