Matrix metalloproteinase-2 (MMP-2) mRNA levels are up-regulated in vehicle-treated NASH mice (1.9 ± 0.7), while gemcabene-treated mice at 100 and 300 mg/kg doses significantly down-regulated the MMP-2 mRNA expression levels (0.5 ± 0.2 and 0.9 ± 0.2, respectively). This evidence concerns the gene MMP2 and metabolic dysfunction-associated steatohepatitis.