APOC3 and metabolic dysfunction-associated steatohepatitis: Similarly, ApoC-III gene expression levels for gemcabene 100 mg/kg and 300 mg/kg were significantly down-regulated compared to the vehicle-treated NASH mice (0.5 ± 0.0 (p<0.01) and 0.4 ± 0.1 (p<0.0001), respectively, compared to 0.7 ± 0.1 (p<0.001)).