In addition, it is reported that l-peptides might bind GRP78 (glucose-regulated protein 78, a verified specific tumor surface marker as well as a promising target for selective cytotoxicity of carcinomas) on the surface of cancer cells (Wang et al., 2016) and l-peptide-linked liposomes loaded with doxorubicin showed a higher efficacy for tumor suppression than liposomal doxorubicin alone, and apparently did not cause side effects in vivo (Wang et al., 2016). Here, HSPA5 is linked to neoplasm.