NHERF1 and neoplasm: Although we cannot attribute a function with the redistribution of EBP50 to the cytoplasm in our cohort, collectively, our data are consistent with a tumour suppressor function at the cell membrane, and oncogenic function in the cytoplasm (Fig. 3), possibly by regulating the PI-3K/AKT/PTEN axis in the cytoplasm and Wnt/β-catenin signalling through the adherens junction proteins E-cadherin and β-catenin at the cell membrane [3, 7, 8].