NHERF1 and neoplasm of oropharynx: In contrast, patients who were either non-smokers or ex-smokers at the time of diagnosis, had p16/HR-HPV-positive oropharyngeal tumours, presented with positive neck nodes, late stage disease, and were more likely to have ‘weak/negligible cytoplasmic’ EBP50 expression (Fig. 3d), suggesting these may have a different pathology from those expressing ‘predominantly cytoplasmic’ EBP50.