It is speculated that high levels of circulating oligosaccharides (in addition to intracellular accumulation) may contribute to the immunodeficiency seen in AM patients, since they bind to interleukin-2 (IL-2) receptors, disturbing IL-2-dependent responses (Zanetta et al. 1998). The gene discussed is IL2; the disease is acute myeloblastic leukemia with maturation.