A third molecule, brodalumab, an IL-17RA blocker, was also evaluated for its effect on enthesitis and no significant effect was found in those patients who had scores of more than 0 for enthesitis at week 12 between the group receiving 140 mg of brodalumab and the group receiving 280 mg of brodalumab, as compared with the placebo group [58]. The gene discussed is IL17RA; the disease is enthesitis.