In patients with pSS, disease duration was negatively correlated to IL-10 (r = − 0.32, p = 0.02), IL-12 (r = − 0.34, p = 0.02) and TNF-α (r = − 0.40, p = 0.004) and positively to TGF-β1 (r = 0.29, p = 0.04). This evidence concerns the gene IL10 and peeling skin syndrome.