Four genes in the autosomes had higher expression and higher methylation in males than in females: PITPNM1, which is necessary for maintaining the normal structure of the endoplasmic reticulum and the Golgi apparatus (31); TTC39C, which is involved in protein-protein interaction (32); DGCR5, which encodes a long noncoding RNA that has been reported as a biomarker for hepatocellular carcinoma (33); and SULT1A1, which encodes the most abundant sulfotransferase enzyme in liver, which catalyzes the sulfonation of many hormones and compounds (34). The gene discussed is DGCR5; the disease is hepatocellular carcinoma.