What’s more, LKB1 and Akt, stabilized by neddylation, regulates energy metabolism in human HCC.22 Additionally, using the Nedd8‐activating enzyme inhibitor MLN4924, the inhibition of neddylation pathway inhibits the growth of HCC cells by inducing autophagy and apoptosis.23 However, the expression of NEDD8, neddylation, and deneddylations enzymes in human HCC and its clinical meaning have not been studied systematically before. Here, NEDD8 is linked to hepatocellular carcinoma.