COPS5 and hepatocellular carcinoma: In fact, it has been reported that COPS5 (also known as JAB1) was upregulated in HCC, and loss of COPS5 could inhibit the growth of HCC cells by restoring the expression of p57.33,34 Jun Yu et al found that UCHL1 was expressed in all normal tissues and immortalized normal epithelial cell lines but was low or silenced in 77% (10/13) of HCC cell lines.35 UCHL1 suppressed the growth of Huh1 and SNU387 cells and appeared to be a functional tumor suppressor in HCC.35 However, they did not detect the expression of UCHL1 in paired human HCC and ANL tissues.