Obesity is one of the most important causes of CVDs.Obesity can disrupt secretion of adipose-derivedadipokines and lead to systemic metabolic dysfunction,inflammation and cardiovascular complications (2-4).According to recent studies, Apelin and its receptor, Apj,have dysregulated expression or secretion patterns incardiovascular system of obese diabetic rats (28). The gene discussed is APLNR; the disease is obesity due to melanocortin 4 receptor deficiency.