PRKN and Charcot-Marie-Tooth disease axonal type 2P: A relatively small number of variants in LRSAM1 havebeen associated with CMT2P, however, the majority ofthem are predicted to interfere with the RING domainand in turn the E3 ubiquitin ligase activity of the protein.Ubiquitination plays a central role within cells and itsdisruption is expected to have an impact on the overallwellbeing of the cell.