LRSAM1 has recently been implicated in Charcot-Marie-Tooth (CMT) pathways but its role remains unclear.LRSAM1 knockdown in zebrafish has been reported tocause delayed neurodevelopment (3), while LRSAM1knockout mice presented only sensitization to acrylamideinducedneurodegeneration with no anatomical or functionalabnormalities (11). Here, LRSAM1 is linked to Charcot-Marie-Tooth disease.