CD44 and gastric cancer: We not only confirm that mtDNA depletion triggerschemoresistance in correlation with an increase anddecrease in CD44 and CD24 positivity respectively inHGC-27 and MKN-45 metastatic GC cell lines, but also,importantly, identified a mtDNA setpoint, at 33-40% ofthat observed in control cells, resulting in the highestlevels of cell surface positivity for anti-CD44 antibodyand chemoresistance.