Apart from part/E2F and Ezh2, other signallingpathways such as Wnt/ß-catenin and RANK/RANKLhave been associated with EMT induction in CSCs.Specifically, increase in RANK/RANKL signalinghas been shown to increase the population of CD44+/CD24- stem cells, and induce EMT and stemness inhuman mammary epithelial cells, thus being involved inBC tumour initiation, progression and metastasis (55). This evidence concerns the gene TNFRSF11A and neoplasm.