Prior studies investigating FOCM‐related genes and response to 5‐FU‐based chemotherapy in CRC patients were largely limited to TYMS and MTHFR variants yielding inconsistent results 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19. This evidence concerns the gene MTHFR and colorectal carcinoma.