p53 pathway can negatively regulate the cell cycle through the activation of p21.37, 38 As a proposed investigation of cell cycle molecules, reduction in p21 it was associated with high‐grade serous carcinoma subtype, and anatomopathological characteristics of lymphatic vascular invasion, bilateral involvement, necrosis, ovarian surface involvement, tumor stage, death, and relapse (Table 2 and Figure 2). This evidence concerns the gene TP53 and serous adenocarcinoma.