Here, we observed that the lower levels of AGR2 protein in ovarian carcinoma were correlated with high‐grade serous carcinoma and characteristics of malignancy, such as lymphatic vascular invasion, bilateral involvement, necrosis, ovarian surface involvement, lymph node metastasis, and relapse (Table 2). The gene discussed is AGR2; the disease is metastatic malignant neoplasm in the lymph nodes.