Nevertheless, the association between SNAI2 overexpression and the presence of lymph node metastasis has already been described by protein and gene analysis in tongue squamous cell carcinoma and breast and colorectal cancers, as well as the correlation of SNAI2 overexpression with N‐Cadherin and Vimentin overexpression.66, 67, 68TWIST1 was overexpressed in 73% of the present cases and more frequently overexpressed in the N+ group. The gene discussed is SNAI2; the disease is tongue squamous cell carcinoma.