TGFB1 and neoplasm: However, in tongue squamous cell carcinoma (in vitro and in tumor tissue samples), an investigation showed that CAIX and ZEB1 protein expression are correlated and that CAIX  ould be regulated by ZEB1.64 A correlation between CAIX and SNAI2 was also reported by IHC analysis in basal‐like breast carcinomas.65 In summary, CAIX may, such as c‐MET, be a less important EMT inducer than TGFB1 in NSCLC patients, without differences depending on the N status, but involving different EMT‐TFs, only in the N+ group of tumors.