2‐DG inhibits glycolysis, targeting HK and also competes with the entrance of extracellular glucose into the cells by GLUTs.38 Other reports showed the effect on tumour cells induced by this compound alone or in combination with other drugs.18, 19, 20, 21 However, few reports showed the effectiveness of 2‐DG in glioma therapy. This evidence concerns the gene HK1 and central nervous system cancer.