Apart from one clinical criterion (vascular thrombosis and/or adverse obstetric event), the revised classification criteria require the persistent detection of anti-phospholipid antibodies (aPL) such as anti-beta2 glycoprotein I (aβ2GPI), anti-cardiolipin (aCL), and/or autoantibodies interfering with coagulation [lupus anti-coagulant (LAC)] for the diagnosis of APS. This evidence concerns the gene ACLY and systemic lupus erythematosus.