A partly overlapping deletion in the 1q22-q23.1 region has been recently described in a patient presenting with intellectual disability and multiple congenital anomalies, and two of the HI genes, NES and MAF2D, were shown to be necessary for normal neuron development in mice (Ikeshima et al. 1995; Park et al. 2010; Aleksiuniene et al. 2018). Here, NES is linked to Intellectual disability.