LMNA and Emery-Dreifuss muscular dystrophy: Since progressive muscle weakness is a principal sign in a number of laminopathies, including Emery-Dreifuss muscular dystrophy, limb-girdle muscular dystrophy, and Charcot-Marie-Tooth type 2B1 and has been reported in the Lmna−/− mice, muscular hypotonia observed in our patient may also be attributed to the abnormal gene expression and functioning of LMNA. In addition, psychomotor retardation manifested by our proband may result not only from hypotonia and muscular weakness, but also from the impediment of the growth of the patient’s brain.