The features associated with LMNA loss-of function mutations arise from primarily affected MSCs and include reduction in muscle mass, defects of bone formation, and craniofacial symptoms, such as delayed closure of sutures as seen in mandibuloacral dysplasia (MAD) and Hutchinson-Gilford progeria (Novelli et al. 2002; De Sandre-Giovannoli et al. 2003; Shen et al. 2003; Yang et al. 2006; Kim et al. 2011). Here, LMNA is linked to Hutchinson-Gilford progeria syndrome.