Consequently, the role of bone in regulating energy homeostasis may provide new insights into the pathogenesis of those disorders: an inversely correlation exists between serum levels of LCN2 and body weight in addition to glycated hemoglobin (HbA1c) in type 2 diabetes patients45 and LCN2 recently emerged as a potential clinical biomarker in multiple sclerosis and age-related cognitive decline.144 However, the biological function of LCN2 secreted by osteoblasts requires validation in humans with more convincing clinical data. This evidence concerns the gene LCN2 and type 2 diabetes mellitus.