Consequently, mice with increased osteoclast activity display increased circulating levels of bioactive GluOCN, improved glucose tolerance and insulin sensitivity, whereas mice lacking osteoclasts have decreased levels of bioactive GluOCN and glucose tolerance.124 In addition, insulin signaling in osteoblasts leads to reduced OPG expression and increased osteoclast activity, resulting in the release of bioactive GluOCN. The gene discussed is INS; the disease is glucose measurement.