In addition, the production of FGF23 by dysplastic bone plays a crucial role in the renal phosphate-wasting syndrome associated with FD.109 These studies make FGF23 a unique member of the FGF family as it functions as a hormone that derives from bone and regulates phosphate metabolism in the kidney, which is critically important for bone health.35,110,111. Here, FGF23 is linked to Fabry disease.