Few fusions (n = 46) contained at least one gene fusion partner that spanned the 8p11-p12 genomic region (ADAM2, ADAM32, ADAM9, ASH2L, BAG4, DDHD2, EIF4EBP1, ERLIN2, FGFR1, HOOK3, PLPP5 (gene alias PPAPDC1B), RAB11FIP1, TACC1, WHSC1L1), of which four fusions were in-frame (ADAM9-HOOK3, BAG4-PDSS2, NUP93-DDHD2, TACC1-EIF4EBP1). In addition, three of the 46 fusion transcripts were found in two samples (ERLIN2-MALAT1, MALAT1-TACC1, NUP93-DDHD2), whereas the other 43 fusions were either unique to a specific tumor specimen or alternative splicing events of the same fusion transcript. The gene discussed is HOOK3; the disease is neoplasm.