Consequently, the Oncofuse Bayesian classifier pipeline classified 83/1,245 (6.7%, range 0–20) fusion transcripts (65 fusion genes) as “driver” fusion events with oncogenic properties, including the COL1A2-TRPS1 and MAST2-PRKCA fusions that were identified in more than one tumor and several other known breast cancer-related genes, e.g. BCL2, ESR1, ERBB2, IGFBP5, TRPS1 (Supplementary Table 4). Here, ESR1 is linked to breast cancer.