DNA copy number analysis revealed recurrent chromothripsis-like events spanning the 8p11-p12 amplicon, including an amplification peak comprised of the histone lysine methyltransferase WHSC1L1 (Wolf-Hirschhorn syndrome candidate 1-like 1), also known as NSD3. WHSC1L1 has been studied extensively to better understand its role in 8p11-p12 amplification in breast carcinoma and other malignancies [17, 20–23]. The gene discussed is NSD3; the disease is breast carcinoma.