ESR1 and breast cancer: Among protein-coding genes, several breast cancer-related genes were predicted to be fusion transcripts with oncogenic potential, e.g. BCL2, ESR1, ERBB2, IGFBP5, TRPS1. Interestingly, we have previously shown that TRPS1 is among other genes spanning chromosome 8q that are hypomethylated in 8p11-p12 breast tumors [12].