BRAF and neoplasm: In summary, here we confirm the adverse prognosis of BRAF mutations in sCRC, and point out their utility, together with the TNM stage, for the identification, already at diagnosis, of a subgroup of sCRC patients (TNM stage IV plus TNM stage III and BRAF mutated patients) who, despite following complete resection of the tumor, still retain a high-risk of recurrence during the first two years after diagnosis.