BRAF and neoplasm: Regarding OS, the TNM stage at diagnosis (p=0.02), the size of the tumor (p=0.005), and the microsatellite instability status (p=0.01) together with the BRAF mutational status (p=0.001), were the only individual parameters that showed an impact on patient outcome, the latter being the only variable with an independent impact on patient OS -p=0.022; HR of 4.4 (95% CI of 0.7-28)- (Table 5).