In lower grade IDH-1 (R132H) mutated astrocytomas without signs of neo-angiogenesis, SLUG (Supplementary Figure 1A) and TWIST (Supplementary Figure 1B) were absent on both IDH-1 (R132H)-mutated glioma cells and tumor-associated blood vessels. This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).